Should be taken with food: Take w/ or immediately after meals.
Contraindications
Hypersensitivity. Patients who have history of stroke, CVA, heart attack, MI, CABG, uncontrolled HTN & CHF (NYHA II-IV). Active
peptic ulcer or inflammatory bowel disease. Hepatic &
renal impairment. Cross-sensitivity w/ aspirin & other NSAIDs.
Impaired renal & liver function. Avoid prolonged treatment for >7 days. Concomitant w/ plasma-protein-binding drugs & anticoagulants. Discontinue treatment if skin rash, diarrhea or other significant GI discomfort occurs. Not recommended during pregnancy & lactation. Not recommended in childn.
Interferes w/ the anti-platelet effect of low-dose aspirin. Displaces warfarin from protein-binding sites & may enhance response to oral anticoagulants. Reduced efficacy of diuretics & other antihypertensive drugs, including ACE inhibitors, angiotensin II antagonist & β-blockers. Increased risk of GI ulceration or bleeding w/ corticosteroids. May increase risk of nephrotoxicity w/ cyclosporine & tacrolimus. Changes in the effects of oral hypoglycemic agents. Elevation of plasma lithium & reduction in renal lithium clearance. Increased plasma levels of methotrexate.
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