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Signs and symptoms include nausea and vomiting and muscle weakness. Severe toxicity occurs after chronic excessive oral doses, often in patients with renal insufficiency. Early manifestations are lethargy, hyporeflexia (decrease reflexes) followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures and respiratory depression.
In case of accidental overdose or at the first sign of any adverse reaction, discontinue use and seek professional assistance immediately.
