As with all potent inhaled anesthetics, sevoflurane may cause dose-dependent cardio-respiratory depression. Most adverse reactions are mild to moderate in severity and are transient in duration. Nausea and vomiting are commonly observed in the post-operative period, at a similar incidence to those found with other inhalation anesthetics. These effects are common sequelae of surgery and general anesthesia which may be due to the inhalational anesthetic, other agents administered intra-operatively or post-operatively and to the patient's response to the surgical procedure. The most frequent adverse events associated with sevoflurane overall were nausea and vomiting. Agitation occurred frequently in children.