Monotherapy or in combination w/ other cancer chemotherapeutic agents in the treatment of solid tumors & hematologic malignancies eg, acute lymphocytic-lymphoblastic & acute myeloblastic leukemias; Wilm's tumor, neuroblastoma, soft tissue sarcomas, osteosarcoma; breast, ovarian, thyroid & gastric carcinoma; malignant lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma, transitional cell bladder carcinoma, bronchogenic carcinoma in which the small cell histologic type is the most responsive & squamous cell carcinoma of the head & neck. Antitumor activity in adult & ped malignancies eg, endometrial, primary hepatocellular carcinoma, non-seminomatous carcinoma of the testis, carcinoma of the prostate, Ewing's sarcoma, rhabdomyosarcoma, multiple myeloma & chronic leukemias. Component of adjuvant therapy in women w/ evidence of axillary lymph node involvement following resection of primary breast cancer & by instillation in the bladder for the topical treatment of superficial bladder tumors.