Primary hypercholesterolemia (type IIa including heterozygous familial hypercholesterolemia), mixed dyslipidemia (type IIb) or homozygous familial hypercholesterolaemia in patients who have not responded adequately to diet & other appropriate measures.
Initially 5-10 mg, may be increased to 20 mg once daily after not less than 4 wk. Severe hypercholesterolemia w/ high CV risk Increased to 40 mg after 4 wk. Concomitant use w/ ciclosporin or fibrate Max: 20 mg daily.
Patients w/ acute liver disease or unexplained persistent raised serum aminotransferase conc. Discontinue use if marked increases in serum aminotransferases or creatinine phosphokinase conc occur. Avoid during pregnancy.
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