Riliz Adverse Reactions

Adverse effects are more common during the first months after the start of treatment with dienogest, and subside with continued treatment. There may be changes in menstrual bleeding pattern, such as spotting, irregular bleeding, or amenorrhea. The most frequently reported adverse effects during treatment with dienogest include headache, breast discomfort, depressed mood, and acne.
Blood and lymphatic system disorders: Anemia.
Metabolism and nutrition disorders: Increased appetite, weight decrease, weight increase.
Psychiatric disorders: Altered mood, anxiety, depressed mood, depression, insomnia, loss of libido, mood swings, nervousness, sleep disorder.
Nervous system disorders: Autonomic nervous system imbalance, disturbance in attention, headache, migraine.
Eye disorders: Dry eye.
Ear and labyrinth disorders: Tinnitus.
Cardiac disorders: Palpitations, unspecific circulatory system disorder.
Vascular disorders: Hypotension.
Respiratory, thoracic and mediastinal disorders: Dyspnea.
Gastrointestinal disorders: Abdominal discomfort, abdominal distension, abdominal pain, constipation, diarrhea, flatulence, gastritis, gastrointestinal inflammation, gingivitis, nausea, vomiting.
Skin and subcutaneous tissue disorders: Abnormal hair growth, acne, alopecia, dandruff, dermatitis, dry skin, hirsutism, hyperhidrosis, onychoclasis, photosensitivity reaction, pigmentation disorder, pruritus.
Musculoskeletal and connective tissue disorders: Back pain, bone pain, decrease of bone mineral density (particularly in adolescents), heaviness in extremities, muscle spasms, pain in extremity.
Renal and urinary disorders: Cystitis, urinary tract infection.
Reproductive system and breast disorders: Amenorrhea, atrophic vulvovaginitis, breast discomfort, breast engorgement, breast induration, breast mass, breast pain, fibrocystic breast disease, genital discharge/vaginal discharge, hot flushes, irregularities in menstrual bleeding, ovarian cyst/hemorrhagic ovarian cyst, pelvic pain, uterine/vaginal bleeding including spotting (consists of dysfunctional uterine bleeding, metrorrhagia, menorrhagia, uterine hemorrhage, vaginal hemorrhage), vaginal candidiasis, vulvovaginal dryness including mucosal dryness.
General disorders and administration site conditions: Asthenic conditions including asthenia, malaise, edema, face edema, irritability.