Proquad Description

Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad), when reconstituted as directed, is a sterile preparation for subcutaneous administration.
Each 0.5 mL dose contains not less than 3.00 log₁₀ TCID₅₀ (50% tissue culture infectious dose) of measles virus; 4.30 log₁₀ TCID₅₀ of mumps virus; 3.00 log₁₀ TCID₅₀ of rubella virus; and a minimum of 3.99 log₁₀ PFU (plaque forming units) of Oka/Merck varicella virus.
Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad) is a combined attenuated live virus vaccine containing measles, mumps, rubella, and varicella viruses. Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad) is a sterile lyophilized preparation of (1) the components of M-M-R* II (Measles, Mumps and Rubella Virus Vaccine Live): Measles Virus Vaccine Live, a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; Mumps Virus Vaccine Live, the Jeryl Lynn (B level) strain of mumps virus propagated in chick embryo cell culture; Rubella Virus Vaccine Live, the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts; and (2) Varicella Virus Vaccine Live (Oka/Merck) (VARIVAX*), the Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells.
The cells, virus pools, bovine serum, and human albumin used in manufacturing are all screened to ensure the absence of adventitious agents.