Profurex Caution For Usage

The dry powder in vials should be stored at temperatures not exceeding 25°C and protected from light. PROFUREX should not be mixed in the syringe with aminoglycoside antibiotics. Suspension of PROFUREX for intramuscular injection and aqueous solutions for direct intravenous injection retain their potency for 5 hours if kept at temperatures not exceeding 25°C and for 48 hours if refrigerated. More diluted solutions, i.e. 1.5 g plus 50 mL Water for Injection, retain their potency for 24 hours if kept at temperatures not exceeding 25°C and for 72 hours if refrigerated.
The color of prepared solution and suspension of PROFUREX may darken on storage.
PROFUREX is compatible with the more commonly used intravenous infusion fluids. It will retain potency for up to 24 hours at room temperature in Sodium Chloride Injection BP 0.9% w/v, 5% Dextrose Injection BP, 0.18% w/v Sodium chloride plus 4% Dextrose Injection BP and Compound Sodium Lactate Injection BP (Hartmann's Solution). The pH of 2.74% w/v Sodium Bicarbonate Injection BP considerably affects the color of the solution is not recommended for the dilution of PROFUREX. However, if required, for patients receiving Sodium Bicarbonate Injection by infusion PROFUREX may be introduced into the tube of the giving set.