Adult 750 mg IM/IV 8 hrly, may be increased to 1.5 g IV 8 hrly. Max: 3-6 g daily.
Childn & infant 30-100 mg/kg/day in 3-4 divided doses.
Most infections 60 mg/kg/day.
Neonate 30-100 mg/kg/day in 2-3 divided doses.
Abdominal, pelvic & orthopedic surgeries 1.5 g IV w/ induction of anesth, may be supplemented w/ 2 x 750 mg IM doses 8 & 16 hr later.
Cardiac, pulmonary, esophageal & vascular surgeries 1.5 g IV w/ induction of anesth, continuing w/ 750 mg IM 8 hrly for a further 24-48 hr.
Total joint replacement 1.5 g mixed dry w/ each pack of methylmethacrylate cement monomer before adding the liqd monomer.
Gonorrhea 1.5 g as single dose, given as 2 x 750 mg IM into different sites.
Moderate renal impairment (GFR 20-50 mL/min) 750 mg every 8 hr.
Marked renal impairment (GFR 20-50 mL/min) 750 mg every 12 hr.
Severe renal impairment (GFR <10 mL/min) 750 mg once daily.
Patients on dialysis 750 mg at the end of each dialysis.
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