PK-Merz Contraindications

Amantadine Sulphate (PK-Merz) 100 mg film-coated tablets must not be used in patients with hypersensitivity to amantadine compounds, Yellow-orange S (E 110) or to any of the excipients of the medicinal product, severe decompensated heart failure (NYHA class IV), cardiomyopathies and myocarditis, 2nd or 3rd degree AV block, existing bradycardia under 55 beats/min, known prolonged QT interval (Bazett QTc > 420 ms) or discernible U-waves or congenital QT syndrome in the family anamnesis, history of serious ventricular arrhythmias including torsade de pointes, simultaneous treatment with budipine or other drugs that prolong the QT interval (see Interactions), reduced levels of potassium or magnesium in the blood.
Amantadine Sulphate (PK-Merz) 100 mg film-coated tablets may be used only with particular caution in patients with prostatic hypertrophy, narrow-angle glaucoma, renal insufficiency (of varying severity; there is a risk of accumulation due to deterioration in renal filtration performance, see Dosage & Administration and Precautions).