Paizu Dosage/Direction for Use

Dosage: The dose and frequency of piperacillin/tazobactam depends on the severity and localisation of the infection and expected pathogens.
Adult and adolescent patients: Infections: The usual dose is 4 g piperacillin/0.5 g tazobactam given every 8 hours.
For nosocomial pneumonia and bacterial infections in neutropenic patients, the recommended dose is 4 g piperacillin/0.5 g tazobactam administered every 6 hours. This regimen may also be applicable to treat patients with other indicated infections when particularly severe.
The following table summarises the treatment frequency and the recommended dose for adult and adolescent patients by indication or condition: (See Table 3.)

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Renal impairment: The intravenous dose should be adjusted to the degree of actual renal impairment as follows (each patient must be monitored closely for signs of substance toxicity; medicinal product dose and interval should be adjusted accordingly): (See Table 4.)

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For patients on haemodialysis, one additional dose of piperacillin/tazobactam 2 g/0.25 g should be administered following each dialysis period, because haemodialysis removes 30%-50% of piperacillin in 4 hours.
Hepatic impairment: No dose adjustment is necessary (see Pharmacology: Pharmacokinetics under Actions).
Dose in elderly patients: No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 40 mL/min.
Paediatric population (2-12 years of age): Infections: The following table summarises the treatment frequency and the dose per body weight for paediatric patients 2-12 years of age by indication or condition: (See Table 5.)

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Renal impairment: The intravenous dose should be adjusted to the degree of actual renal impairment as follows (each patient must be monitored closely for signs of substance toxicity; medicinal product dose and interval should be adjusted accordingly): (See Table 6.)

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For children on haemodialysis, one additional dose of 40 mg piperacillin/5 mg tazobactam/kg should be administered following each dialysis period.
Use in children aged below 2 years: The safety and efficacy of piperacillin/tazobactam in children 0-2 years of age has not been established.
No data from controlled clinical studies are available.
Treatment duration: The usual duration of treatment for most indications is in the range of 5-14 days. However, the duration of treatment should be guided by the severity of the infection, the pathogen(s) and the patient's clinical and bacteriological progress.
Method of administration: Piperacillin + Tazobactam powder for injection is administered by intravenous infusion (over 30 minutes). For instructions on reconstitution of the medicinal product before administration, see Special precautions for disposal and other handling.