Paizu

Per 2 g/250 mg inj Piperacillin Na 2 g, tazobactam Na 250 mg. Per 4 g/500 mg inj Piperacillin Na 4 g, tazobactam Na 500 mg

Severe pneumonia including hospital-acquired & ventilator-associated pneumonia; complicated UTI (including pyelonephritis), intra-abdominal infections, skin & soft tissue infections (including diabetic foot infections) in adults & adolescents. Patients w/ bacteraemia that occurs in association w/, or is suspected to be associated w/, any of infections mentioned. Management of neutropenic patients w/ fever suspected to be due to a bacterial infection. Complicated intra-abdominal infections in childn 2-12 yr. Management of neutropenic childn w/ fever suspected to be due to a bacterial infection.

Adult & adolescent Severe pneumonia, neutropenia w/ fever suspected to be due to a bacterial infection Piperacillin 4 g/tazobactam 500 mg every 6 hr. Complicated UTI (including pyelonephritis), intra-abdominal infections, skin & soft tissue infections (including diabetic foot infections) Piperacillin 4 g/tazobactam 500 mg every 8 hr. Renal impairment CrCl >40 mL/min No dose adjustment necessary, 20-40 mL/min Max: piperacillin 4 g/tazobactam 500 mg every 8 hr, <20 mL/min Max: piperacillin 4 g/tazobactam 500 mg every 12 hr. Patients on haemodialysis 1 additional dose of piperacillin 2 g/tazobactam 250 mg should be administered following each dialysis period. Childn 2-12 yr Neutropenia w/ fever suspected to be due to bacterial infections Piperacillin 80 mg/tazobactam 10 mg/kg every 6 hr. Max: 4 g/500 mg/dose over 30 min. Complicated intra-abdominal infections Piperacillin 100 mg/tazobactam 12.5 mg/kg every 8 hr. Max: 4 g/500 mg/dose over 30 min. Renal impairment CrCl >50 mL/min No dose adjustment needed, CrCl ≤50 mL/min Piperacillin 70 mg/tazobactam 8.75 mg/kg every 8 hr. Childn on haemodialysis 1 additional dose of piperacillin 40 mg/tazobactam 5 mg/kg should be administered following each dialysis period. Treatment duration: 5-14 days for most indications.

Hypersensitivity to piperacillin, tazobactam or any other penicillin-antibacterial agent. History of acute severe allergic reaction to any other β-lactam active substances (eg, cephalosporin, monobactam or carbapenem).

Previous hypersensitivity reactions to penicillins, other β-lactam agents (eg, cephalosporin, monobactam or carbapenem) & other allergens. Closely monitor if patients develop a skin rash & discontinue if lesions progress. Discontinue in cases of antibiotic-induced pseudomembranous colitis; if bleeding manifestations occur. Emergence of resistant organisms, which might cause super-infections. Perform periodic assessment of haematopoietic function especially during prolonged therapy. Convulsions in high doses especially in patients w/ impaired renal function. Hypokalaemia; periodic electrolyte determinations in patients w/ low K reserves or those receiving concomitant medicinal products that may lower K levels. May lead to false +ve results w/ non-enzymatic methods of measuring urinary glucose, chemical urine protein measurement methods & Bio-Rad Laboratories Platelia Aspergillus EIA tests; direct Coombs test may be +ve. Renal impairment or haemodialysis patients. Pregnancy & lactation. Childn <2 yr.

Diarrhoea. Candida infection; thrombocytopenia, anaemia; insomnia; headache; abdominal pain, vomiting, nausea, constipation, dyspepsia; rash, pruritus; pyrexia, inj site reaction; increased ALT, AST, blood creatinine, blood alkaline phosphatase & blood urea, decreased total protein & blood albumin, Coombs direct test +ve, prolonged aPTT.

May affect blood coagulation system including thrombocyte function w/ heparin & oral anticoagulants. Longer t_½ & lower renal clearance w/ probenecid. Piperacillin: Prolongation of neuromuscular blockade of vecuronium & any of the non-depolarising muscle relaxants. May reduce excretion of MTX. Inactivation of tobramycin & gentamicin in patients w/ severe renal impairment. Increased incidence of acute kidney injury w/ vancomycin.

Penicillins

J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Rx