Each tablet contains: Folic Acid 5 mg.
Pharmacology: Folic Acid is rapidly absorbed from the gastrointestinal tract, mainly from the duodenum and jejunum. Dietary folates are stated to have about half the bioavailability of crystalline folic acid. The naturally occurring folate polyglutamates are largely deconjugated, and then reduced by dihydrofolate reductase in the intestines to form 5-methyltetrahydrofolate, which appears in the portal circulation, where it is extensively bound to plasma proteins. Folic Acid given therapeutically enters the portal circulation largely unchanged, since it is a poor substrate for reduction by dihydrofolate reductase. It is converted to the metabolically active form 5-methyltetrahydrofolate in the plasma and liver.
The principal storage site of folate is the liver, it is also actively concentrated in the CSF.
Folate undergoes enterohepatic circulation. Folate metabolites are eliminated in the urine and folate in excess of body requirements is excreted unchanged in the urine. Folate is distributed into breast milk. Folic acid is removed by hemodialysis.
Folic acid is indicated in the treatment and prevention of folate deficiency state. It is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring.
For the treatment of folate-deficient megaloblastic anemia: 5 mg or 1 tablet daily for 4 months; up to 15 mg or 3 tablets daily in malabsorption states. Continued administration of 5 mg folic acid every 1 to 7 days may be necessary in chronic hemolytic states depending on the diet and rate of hemolysis.
For prevention of neural tube defects in the offspring of pregnant women and women with child-bearing potential: 5 mg or 1 tablet daily starting before pregnancy and continued through the first trimester or as prescribed by the physician.
No information available.
Folic acid should never be given alone or with inadequate amounts of Vitamin B12 for the treatment of undiagnosed megaloblastic anemia, since folic acid may produce a hematopoietic response in patients with megaloblastic anemia due to vitamin B12 deficiency without preventing aggravation of neurological symptoms.
Folic Acid is generally well tolerated. Gastrointestinal disturbances and hypersensitivity reactions have been reported rarely.
Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol, and folic acid antagonists such as methotrexate, pyrimethamine, triamterene, trimethoprim, and sulfonamides.
B03BB01 - folic acid ; Belongs to the class of folic acid and derivatives. Used in the treatment of anemia.
Obsure tab 5 mg
100's;30's
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