Treatment & prevention of folate deficiency state. For women of child-bearing potential & pregnant women to protect against neural tube defects in their offspring.
Folate-deficient megaloblastic anemia 5 mg daily for 4 mth. Malabsorption states Up to 15 mg daily. Chronic hemolytic states 5 mg every 1-7 days depending on the diet & rate of hemolysis. Prevention of neural tube defects in the offspring of pregnant women & women w/ child-bearing potential 5 mg daily starting before pregnancy & continued through the 1st trimester.
View Obsure overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Special Precautions
Should never be given alone or w/ inadequate amounts of vit B12 for the treatment of undiagnosed megaloblastic anemia; may produce a hematopoietic response in patients w/ megaloblastic anemia due to vit B12 deficiency w/o preventing aggravation of neurological symptoms.
Folate deficiency states may be produced by antiepileptics, OCs, anti-TB drugs, alcohol, & folic acid antagonists eg, MTX, pyrimethamine, triamterene, trimethoprim, & sulfonamides.
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