Mycin Adverse Reactions

Adverse nephrotoxic (renal) effects, as demonstrated by the presence of casts, cells or protein in the urine or by rising BUN, NPN, serum creatinine and oliguria have been reported particularly in patients with renal impairment and those treated with larger doses and for longer periods than recommended. Neurotoxicity manifested by adverse effects on both vestibular and auditory branches of the eighth cranial nerves has been reported, primarily in patients, with renal impairment and those treated with large doses and for longer periods than recommended. Symptoms include dizziness, tinnitus, vertigo, roaring in the ears and hearing loss, which, as with other aminoglycosides may be irreversible. Other factors contributing to increased toxicity may include excessive dosage, dehydration and exposure to other ototoxic drugs. Peripheral neuropathy or encephalopathies, including numbness, skin tingling, muscle twitching, convulsions and a myasthenia gravis-like syndrome have been reported.
Other reported adverse reactions include respiratory depression, lethargy, confusion, depression, visual disturbances, decreased appetite, weight loss, hypotension, and hypertension, rash, itching, urticaria, generalized burning, laryngeal edema, anaphylactoid reactions, fever, headache, nausea, vomiting, increased salivation, stomatitis, purpura, pseudotumor cerebri, acute organic brain syndrome, pulmonary fibrosis, alopecia, joint pain, transient hepatomegaly and splenomegaly.