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Omeprazole may interfere with the absorption of drugs like: ketoconazole, ampicillin, iron salts, digoxin, cyanocobalamin where gastric pH is an important determinant of bioavailability.
There are clinical reports of interaction with other drugs like: cyclosporine, disulfiram, benzodiazepines which are metabolized via the cytochrome P450 (CYP450) system.
Coadministration of omeprazole and clarithromycin may result in increase in plasma levels.
Omeprazole increases the half-life of diazepam, probably caused by inhibition oxidative metabolism. Plasma levels were also increased and total clearance of diazepam was decreased.
Omeprazole reduced the plasma clearance of phenytoin and increased its half-life caused by inhibilion of oxidative metabolism.
Coadministration of sucralfate may delay absorption and reduced omeprazole bioavailabillty. Therefore, take omeprazole 30 minutes prior to sucralfate.
