Peptic ulcer 20 mg once daily.
Severe cases 40 mg. Maintenance dose: 10-20 mg once daily.
Duodenal ulcer 20 mg once daily for 4-8 wk.
Duodenal ulcer associated w/ H. pylori Triple therapy: Omeprazole 20 mg + clarithromycin 500 mg + amoxicillin 1,000 mg bid for 10 days. (If an ulcer is present at the initiation of therapy: Continue taking 20 mg for additional 18 days); or omeprazole 20 mg + clarithromycin 250 mg + metronidazole 500 mg or tinidazole 500 mg each given bid for 1 wk; or 20 mg once daily + amoxicillin 500 mg + metronidazole 500 mg both given tid for 1 wk. Dual therapy: 40 mg once daily + clarithromycin 500 mg tid for 14 days. (If an ulcer is present at the initiation of therapy: Continue taking 20 mg for additional 14 days); 40 mg once daily + amoxicillin 750 mg bid for 2 wk.
Gastric ulcer 20 mg once daily for 4 wk.
Patient w/ poorly responsive gastric ulcer 40 mg once daily for 8 wk.
GERD 20-40 mg once daily for 4-12 wk. Maintenance therapy: 20 mg once daily.
Dyspepsia Initially 10 mg once daily.
Patient w/ epigastric pain or discomfort w/ or w/o heartburn 20 mg once daily for 4 wk.
Patient w/ hepatic impairment 10-20 mg once daily.
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