Logimax Use In Pregnancy & Lactation

Pregnancy: Felodipine/Metoprolol succinate (LOGIMAX) must not be given during pregnancy.
There is a lack of adequate data on treatment of pregnant women with felodipine. Felodipine must not be used during pregnancy, as fetal damage was seen in animal studies (see Pharmacology: Toxicology: Preclinical safety data under Actions). Calcium antagonists can inhibit premature contractions in the uterus, but definite confirmation of labor being prolonged in the case of a full-term pregnancy is lacking. A risk of fetal hypoxia may occur in the event of hypotension in the mother and reduced perfusion of the uterus on account of redistribution of the blood supply as a result of peripheral vasodilatation.
Metoprolol should be given during pregnancy and lactation only if it is absolutely necessary. β-receptor blockers can cause bradycardia in the fetus and new-born, and in the breast-fed infant. During the last trimester and in connection with parturition, therefore, the previously mentioned should be borne in mind when prescribing this preparation.
Lactation: Felodipine and metoprolol pass into breast milk. If the nursing mother takes therapeutic doses of felodipine, only a very small dose is transmitted to the infant via the breast milk. There is insufficient experience of felodipine treatment during lactation to permit an assessment of the risks for the infant. Felodipine is therefore not recommended during lactation. In cases in which the medical benefit of continued treatment is considered to predominate, the alternative of discontinuing breast-feeding should be considered.