Logimax

Felodipine 5 mg, metoprolol succinate 47.5 mg

HTN.

Initially 1 tab once daily in the morning, may be increased to bid if required.

May be taken with or without food: Swallow whole, do not divide/chew/crush. May be taken w/ a light meal w/ a low fat & carbohydrate content.

Hypersensitivity to felodipine, metoprolol, other dihydropyridines or β-blockers. Unstable angina pectoris; degree II & III AV block; unstable uncompensated heart failure (pulmonary edema, hypoperfusion or hypotension), continuous or intermittent inotropic therapy w/ β-receptor agonism; symptomatic bradycardia or hypotension; sick sinus syndrome; cardiogenic shock; severe peripheral vascular disease w/ threat of gangrene; suspected acute MI w/ heart rate <45 beats/min, P-Q interval >0.24 sec or systolic BP <100 mmHg.

May exacerbate symptoms of peripheral vascular disease (eg, intermittent claudication). Aortic stenosis; heart failure following acute MI; acute MI; hypotension which can cause myocardial ischemia in susceptible subjects; severe acute pathological conditions w/ metabolic acidosis. Not to be used for 1st treatment of previously untreated patients; patients w/ latent or manifest cardiac insufficiency w/o concomitant treatment. May affect carbohydrate metabolism or mask hypoglycemia. AV conduction time may be exacerbate (possibly leading to AV block). Patients w/ prinzmetal's angina; pheochromocytoma. Adequate bronchodilator therapy must be given concomitantly in cases of bronchial asthma or other COPD. May make treatment of anaphylactic reaction more difficult. Avoid concomitant use w/ digitalis; verapamil (IV); CYP3A4 inducers, potent CYP3A4 inhibitors & grapefruit juice. Abrupt discontinuation may exacerbate chronic heart failure & increase risk of MI & sudden death especially in high-risk patients; discontinue gradually over a 1-2 wk period. Do not w/draw in patients who are undergoing surgery. Severely impaired renal function (GFR <30 mL/min). Impaired hepatic function. May impair ability to drive or operate machinery. Not to be given during pregnancy. Not recommended during lactation.

Ankle swelling, headache, dizziness, fatigue; facial redness; nausea. Metoprolol: Peripheral cold in extremities, bradycardia; abdominal pain, vomiting, diarrhea, constipation.

Felodipine: May affect plasma conc w/ drugs that inhibit or induce CYP3A4. Increased metabolism w/ CYP450 inducers eg, carbamazepine, phenytoin, phenobarb, rifampicin & St. John's wort (Hypericum perforatum). Increased C_max & AUC w/ CYP450 inhibitors eg, azole antifungal agents (eg, itraconazole, ketoconazole), macrolide antibiotics (eg, erythromycin) & HIV PIs; grapefruit juice; cyclosporine; cimetidine. Increased conc of tacrolimus. Metoprolol: May affect plasma conc w/ drugs that inhibit CYP2D6 eg, quinidine, terbinafine, paroxetine, fluoxetine, sertraline, celecoxib, propafenone & diphenhydramine. Induced metabolism w/ barbiturates, rifampicin. Increased plasma conc & inhibited metabolism w/ propafenone, quinidine. Bradycardia & fall in BP w/ verapamil. Additive -ve inotropic effects w/ class I antiarrhythmics eg, disopyramide. Reduced clearance & potentiated effects w/ diphenhydramine. Potentiated hypertensive reaction of sudden w/drawal of clonidine. Pronounced bradycardia w/ diltiazem. Counteract the antihypertensive effect w/ NSAIDs. May cause paradoxical hypertensive reactions w/ high dose of phenylpropanolamine. Marked HTN & bradycardia w/ epinephrine. Increased plasma levels & β-blockade w/ quinidine. Pronounced sinus bradycardia w/ amiodarone. Potentiated cardiodepressive effects w/ inhalation anesth. Other β-receptor blockers (eg, eye drops) or MAO inhibitors; antidiabetic drugs.

Beta-Blockers / Calcium Antagonists

C07FB02 - metoprolol and felodipine ; Belongs to the class of selective beta-blocking agents in combination with other antihypertensives. Used in the treatment of cardiovascular diseases.

Rx