Silybin: GI distress, itching & headache may occur rarely.Phosphatidylcholine: Nausea, diarrhea, excessive fullness & increased salivation have occasionally been reported.
Silybin: May increased the effects of drugs metabolized by CP450 system (eg, erythromycin, nifedipine, tamoxifen, warfarin, clopidogrel, fexofenadine). May reduce effect of metronidazole. May decrease insulin requirements of diabetic patients w/ alcoholic liver cirrhosis. Milk thistle: May reduce the effectiveness of OCs.
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