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Pharmacology: Pharmacokinetics: Levofloxacin is rapidly and almost completely absorbed following oral administration with peak plasma concentrations achieved within an hour of a dose. It is distributed into body tissues including the bronchial mucosa and lungs, but penetration into CSF is relatively poor.
Levofloxacin is approximately 30 to 40% bound to plasma proteins. It is only metabolized into a small degree to inactive metabolites. The elimination half-life of levofloxacin is 6 to 8 hours, although this may prolong in patients with renal impairment. Levofloxacin is excreted largely unchanged, primarily in the urine. It is not removed by haemodialysis or peritoneal dialysis.
