Pharmacology: Pharmacokinetics: Absorption of Levetiracetam with peak plasma concentrations occurring in about an hour following oral administration in fasted subjects. The oral bioavailability of Levetiracetam tablet is 100% and the tablet and oral solution are bioequivalent in rate and extent of absorption. Food does not affect the extent of absorption or Levetiracetam but it decreases Cmax by 20% and delays Tmax by 1.5 hours. Levetiracetam is not extensively metabolized in humans. The major metabolic pathway is the enzymatic hydrolysis of the acetamide group. which produces the carboxylic acid, ucb L057 (24% of dose) and is not dependent on any liver cytochrome P450 isoenzymes. Levetiracetam plasma half-life in adults is 7±1 hour and is unaffected by either dose or repeated administration. Levetiracetam is eliminated from the systemic circulation by renal excretion as unchanged drug which represents 66% of administered dose.
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