Lacipil Adverse Reactions

Data from large clinical trials (internal and published) were used to determine the frequency of very common to uncommon adverse reactions.
The following convention has been used for the classification of frequency: very common ≥ 1/10, common ≥ 1/100 and <1/10, uncommon ≥ 1/1000 and <1/100, rare ≥1/10000 and <1/1000, very rare <1/10000.
Lacidipine (Lacipil) is usually well tolerated. Some individuals may experience minor side-effects which are related to its known pharmacological action of peripheral vasodilation. Such effects, indicated by a hash (#), are usually transient and usually disappear with continued administration of Lacidipine (Lacipil) at the same dosage.
Psychiatric disorders: Very rare: Depression.
Nervous system disorders: Common: Headache, dizziness. Very rare: Tremor.
Cardiac disorders: Common: Palpitation, tachycardia. Uncommon: Aggravation of underlying angina, syncope, hypotension.
As with other dihydropyridines aggravation of underlying angina has been reported in a small number of individuals, especially at the start of treatment. This is more likely in patients with symptomatic ischaemic heart disease.
Vascular disorders: Common: Flushing.
Gastrointestinal disorders: Common: Stomach discomfort, nausea. Uncommon: Gingival hyperplasia.
Skin and subcutaneous tissue disorders: Common: Skin rash (including erythema and itching). Rare: Angioedema, urticaria.
Renal and urinary disorders: Common: Polyuria.
General disorders and administration site conditions: Common: Asthenia, oedema.
Investigations: Common: Reversible increase in alkaline phosphatase (clinically significant increases are uncommon).