Intermittent IV Adult & childn ≥40 kg Broncho-pulmonary infections in cystic fibrosis 100-150 mg/kg/day every 8 hr. Max daily dose: 9 g.
Febrile neutropenia, nosocomial pneumonia, bacterial meningitis, bacteraemia 2 g every 8 hr.
Bone & joint infections, complicated skin & soft tissue infections, complicated intra-abdominal infections, peritonitis associated w/ dialysis in patients on CAPD, chronic suppurative otitis media, malignant otitis externa 1-2 g every 8 hr.
Complicated UTI 1-2 g every 8 hr or 12 hr.
Pre-op prophylaxis for TURP 1 g at induction of anaesth, & 2nd dose at catheter removal.
Infant, toddler >2 mth & childn <40 kg Complicated UTI, chronic suppurative otitis media, malignant otitis externa, bone & joint infections, complicated skin & soft tissue infections, complicated intra-abdominal infections & peritonitis associated w/ dialysis in patient on CAPD 100-150 mg/kg/day in 3 divided doses. Max daily dose: 6 g.
Neutropenia, broncho-pulmonary infections in cystic fibrosis, bacterial meningitis, bacteraemia 150 mg/kg/day in 3 divided doses. Max daily dose: 6 g.
Neonate & infant ≤2 mth 25-60 mg/kg/day in 2 divided doses in most infections.
Elderly >80 yr Not to exceed 3 g daily dose.
Patient w/ renal impairment Initial loading dose of 1 g, maintenance dose should be based on CrCl.
Continuous infusion Febrile neutropenia, nosocomial pneumonia, bacterial meningitis, bacteraemia, bone & joint infection, complicated skin & soft tissue infection, complicated intra-abdominal infection, peritonitis associated w/ dialysis in patient on CAPD Adult & childn ≥40 kg Loading dose: 2 g followed by 4-6 g continuous infusion every 24 hr.
Infant, toddler >2 mth & childn <40 kg Loading dose: 60-100 mg/kg followed by a continuous infusion 100-200 mg/kg/day. Max daily dose: 6 g.
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