Hydrocortisone may be given intravenously, by slow injection or infusion, in the form of water-soluble derivatives such as Hydrocortisone sodium succinate or Hydrocortisone sodium phosphate when a rapid effect is required in emergencies: such conditions are acute adrenocortical insufficiency caused by Addisonian post-adrenalectomy crises, by the abrupt accident withdrawal therapy in corticosteroid treated patients, or by the inability of the adrenal glands to cope with increased stress in such patients certain allergic emergencies such as anaphylaxis; acute severe asthma and shock.
The usual dose is the equivalent of 100 to 500 mg of Hydrocortisone, repeated 3 or 4 times in 24 hrs, according to the severity of the condition and the patients response.
Children: Up to 1 year of age may be given 25 mg, those aged 1 to 5 years 50 mg, and those aged 6-12 years 100 mg. For local administration by injection into soft tissues Hydrocortisone in the form of the sodium phosphate or sodium succinate esters is usually employed; doses in terms of Hydrocortisone are usually 100 mg to 200 mg. For intra-articular injection Hydrocortisone acetate is usually used in doses of 5 to 50 mg depending upon the size of the joint. Or as prescribed by the physician.