Hemanex Overdosage

There are limited data on tranexamic acid overdosage. Symptoms may include dizziness, headache, nausea, vomiting, diarrhea, hypotension, or orthostatic hypotension.
There is no known antidote for tranexamic acid overdose. In cases of overdose, discontinue treatment and institute symptomatic and supportive measures as required. Activated charcoal may decrease absorption if given within one or two hours after ingestion. Administer activated charcoal via a nasogastric tube once the airway is protected in patients who are not fully conscious or have impaired gag reflex.
Monitor vital signs to detect a possible hypotensive episode. In patients with severe vomiting or diarrhea, monitor fluid and electrolyte levels and administer intravenous fluids and replace electrolytes as necessary. Monitor urine output and maintain adequate diuresis. Monitor for clinical evidence of thromboembolic complications (e.g., chest pain, shortness of breath, flank pain, extremity pain). Because there is a risk of thrombosis in predisposed individuals, anticoagulant therapy should be considered in these patients. In symptomatic patients, support cardiac and respiratory function. Monitor blood count, renal function, pulse oximetry and/or blood gases and obtain a chest x-ray. Obtain an ECG and institute continuous cardiac monitoring.