5-FU is used for the treatment of the following malignancies: Carcinoma of the colon or rectum (Colorectal carcinoma): Alone or in combination with leucovorin for the treatment of advanced colorectal cancer.
Breast cancer: In combination chemotherapy as an adjunct to surgery in women with breast cancer.
5-FU has also shown activity in the following malignancies: Gastric cancer.
Primary hepatic cancer.
Pancreatic cancer.
Uterine (particularly cervical) cancer.
Ovarian cancer.
Bladder cancer.