IV infusion 15 mg/kg daily over 4 hr. Alternatively daily dose may be infused over 30-60 min or may be given as a continuous IV infusion over 24 hr. Max: 1 g.
IV inj 12 mg/kg daily for 4 consecutive days. If no toxic effects are observed, 6 mg/kg on days 6, 8, 10 & 12. Max: 800 mg. Alternatively, 15 mg/kg as single IV inj once a wk throughout the course.
Intra-arterial infusion 5-7.5 mg/kg/day as 24-hr intra-arterial continuous drip infusion. Maintenance therapy: Initial therapy should be repeated at intervals of 30 days after the last dose of the previous course. Alternatively when toxicity from initial course of therapy has subsided, 10-15 mg/kg single wkly maintenance may be administered. Max: 1 g. Combination therapy w/ leucovorin: 9-10 mg/kg IV inj for 5 days after 5-12 mg/kg leucovorin for 5 days, repeat course every 4 wk.
Poor risk patient IV inj Initial dose: 6 mg/kg/day for 3 days. If no toxic manifestations are observed, 3 mg/kg is given on days 5, 7, 9. Repeat course every 30 days. Max: 400 mg.
IV infusion 6 mg/kg diluted in 500 mL 0.9% NaCl or 5% dextrose given once a day over 4 hr until signs of toxicity are observed usually w/in 8-15 days.
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