Flupenxol Adverse Reactions

Significant: Extrapyramidal symptoms (e.g. akathisia, dystonia, tardive dyskinesia), QT prolongation, VTE, cerebrovascular events, anticholinergic effects (e.g. xerostomia, blurred vision, constipation, urinary retention), blood dyscrasias (e.g. agranulocytosis, neutropenia, leucopenia, thrombocytopenia), diabetic ketoacidosis, oesophageal dysmotility and aspiration, falls, orthostatic hypotension, impaired core body temperature regulation, increased prolactin levels; withdrawal symptoms. Rarely, lens opacity.
Cardiac disorders: Palpitation, tachycardia.
Eye disorders: Abnormal vision, accommodation disorder.
Gastrointestinal disorders: Nausea, vomiting, dyspepsia, diarrhoea, sialorrhoea.
General disorders and administration site conditions: Fatigue, asthenia.
Investigations: Increased weight.
Metabolism and nutrition disorders: Increased appetite.
Musculoskeletal and connective tissue disorders: Myalgia.
Nervous system disorders: Dizziness, drowsiness, headache, hyper- or hypokinesia, tremor.
Psychiatric disorders: Depression, insomnia, nervousness, agitation, disturbance in attention.
Renal and urinary disorders: Micturition disorder.
Reproductive system and breast disorders: Decreased libido.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Skin and subcutaneous tissue disorders: Hyperhidrosis, pruritus.
Potentially Fatal: Suicidal thoughts or attempts, arrhythmias, neuroleptic malignant syndrome.