Evaprost Adverse Reactions

The adverse effects of Evaprost are generally dose-related, transient and reversible when therapy ends. The most frequent adverse reactions observed are related to its contractile effects on smooth muscle ie, vomiting, diarrhea, hyperpyrexia and flushing.
In patients studied, approximately ²/₃ experienced ¹/₂ vomiting and diarrhea, approximately ¹/₃ had nausea, ¹/₈ had a temperature increase >20°F and ¹/₁₄ experienced flushing.
The pretreatment or concurrent administration of antiemetic and antidiarrheal drugs decreases considerably the very high incidence of gastrointestinal effects common with all prostaglandins used for abortion. Their uses should be considered an integral part of the management of patients undergoing abortion with Evaprost.
Of those patients experiencing temperature elevations, approximately ¹/₁₆ had a clinical diagnosis of endometritis. The remaining temperature elevations returned to normal within several hours after the last injection. The adverse effects observed during the use of Evaprost for abortion and for hemorrhage, not all of which are clearly drug-related, in decreasing order of frequency include: Vomiting, diarrhea, nausea, flushing or hot flashes, chills or shivering, coughing, headaches, endometritis, hiccough, dysmenorrhea-like pain, paresthesia, backache, muscular pain, breast tenderness, eye pain, drowsiness, dystonia, asthma, injection site pain, tinnitus, vertigo, vaso-vagal syndrome, dry mouth, hyperventilation, respiratory distress, hematemesis, taste alterations, urinary tract infection, septic shock, torticollis, lethargy, hypertension, tachycardia, pulmonary edema, endometritis from IUCD, nervousness, nosebleed, sleep disorders, dyspnea, tightness in chest, wheezing, posterior cervical perforation, weakness, diaphoresis, dizziness, blurred vision, epigastric pain, excessive thirst, twitching eyelids, gagging or retching, dry throat, choking sensation, thyroid storm, syncope, palpitations, rash, upper respiratory infection, leg cramps, perforated uterus, anxiety, chest pain, retained placental fragment, shortness of breath, fullness of throat, uterine sacculation, faintness or light-headedness and uterine rupture.
The most common complications when Evaprost was utilized for abortion, requiring additional treatment after discharge from the hospital were endometritis, retained placental fragments, and excessive uterine bleeding, occurring in about 1 in every 50 patients.
Potentially Fatal: Severe cardiovascular system disorders including fatal hypertension, tachypnea, pyrexia and myocardial infarction (in patients with high risk factors) following intra-amniotic or intravaginal administration. Convulsion and electrocardiogram (ECG) changes, amniotic fluid embolism and uterine rupture, fetal distress and rarely fetal death during induction of labor.