Eposino Dosage/Direction for Use

Eposino should be administered through SC and IV 2-3 times/week under physician's direction. Dosage can be changed according to anemia status, age and other related factors of patients.
Treatment Period: The initial dosage for the patients receiving hemodialysis is 100-150 iu/kg, and for those not on hemodialysis is 75-100 iu/kg/week. If hematocrit increase is not as expected (<0.5 vol/week), the dosage can be changed after 4 weeks of initial treatment to increase the dose to 15-30 iu/kg/week but not more than 30 iu/kg/week. The expected rise of hematocrit should be in range of 30-33% v/v, not higher than 34% v/v.
Maintenance Period: If the hematocrit has reached to 30-33% v/v and/or the hemoglobin has reached 100-110 g/L, the maintenance treatment starts. The dosage should be ²/₃ of the initial dosage on this stage. The hematocrit should be monitored once every 2-4 weeks so as to adjust the dosage to maintain hematocrit and hemoglobin at the proper level as well as to avoid erythropoiesis to be formed too quickly. Eposino is usually for long-term use, however, the therapy with Eposino might be stopped for special cases.