Adult ≥16 yr 1,000 mg/day, daily dose given in 2 divided doses (500 mg bid), may be increased in steps of 1 g every 2-4 wk until effective antiepileptic control is achieved. Max: 3 g daily. Childn <50 kg 20 mg/kg daily, may be increased in steps of 20 mg/kg every 2 wk to max of 60 mg/kg daily; >50 kg Adult dose. Monotherapy 500 mg daily, increased after 2 wk to 1 g daily. Further increases may be made in steps of 500 mg every wk up to max of 3 g daily.
Patients undergoing hemodialysis. W/drawal of therapy. Renal impairment & severe hepatic impairment. Not recommended during pregnancy & in women of childbearing potential not using contraception, & lactation.
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