View Dimezine overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to dimenhydrinate, cinnarizine, diphenhydramine or other antihistamines of similar structure. Patients w/ angle-closure glaucoma, convulsions, suspicion of raised ICP, & alcohol abuse or urine retention due to urethroprostatic disorders. Severe renal impairment (CrCl ≤25 mL/min) & hepatic impairment.
Hypotensive patients; patients w/ conditions that might be aggravated by anticholinergic therapy eg, raised IOP, pyloro-duodenal obstruction, prostatic hypertrophy, HTN, hyperthyroidism or severe CHD; Parkinson's disease. May have minor influence on the ability to drive & use machine. Not recommended during pregnancy. Not to be used during lactation.
Potentiated effects w/ MAOIs, procarbazine. Potentiates the effects of CNS depressants including alcohol, barbiturates, narcotic analgesics & tranquilizers. Enhance the effects of antihypertensives, ephedrine & anticholinergics eg, atropine & TCAs. Masks the ototoxic symptoms & response to allergic skin test w/ amino glycosidic antibiotics. Concomitant use w/ class Ia & III antiarrhythmics may prolong QT interval.
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