Cyclophosphamide should not be taken by patients with known hypersensitivity to oxazaphosphorines and in cases of severe bone marrow depression.
Use in Pregnancy: Cyclophosphamide can cause fetal harm when administered to a pregnant woman. Therefore, if this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Women of child bearing potential should be advised to avoid pregnancy during Cyclophosphamide therapy.
Use in Lactation: Cyclophosphamide is excreted in breast milk. Therefore, nursing should be discontinued while the patient is on Cyclophosphamide therapy.