Cyclophos Caution For Usage

500 mg: Directions for Reconstitution: The IV preparation is dissolved in 25 mL of sterile water for injection to yield a concentration of 20 mg/mL. The vials should be shaken until complete dissolution of the dry substance is obtained. A solution thus prepared is added to 250 mL 5% glucose and administered as a brief infusion of 30 min. Single dose. Discard any remaining portion.
1 g: Directions for Reconstitution/Dilution: Dissolve the contents in 50 mL of sterile water for injection. Shake until dissolved.
The IV preparation is dissolved in sterile water for injection to yield a concentration of 20 mg/mL. The vial should be shaken until complete dissolution of the dry substance is obtained. Thus, the prepared solution is added to 250 mL of 5% glucose and is administered as a brief infusion for 30 min.
Special Precautions for Disposal and Other Handling: For intravenous administration: Cyclophosphamide Injection is compatible with the following infusion solutions: sodium chloride solution, glucose solution, sodium chloride and glucose solution, sodium chloride and potassium chloride solution, and potassium chloride and glucose solution.
For oral administration: Cyclophosphamide reconstituted Injection may be dissolved in Aromatic Elixir USP.
General instructions: If vials are stored above the recommended temperature this can cause degradation of the active ingredient, identifiable by a yellow melted appearance to the vial contents. Vials containing melted material should not be used.
Cyclophosphamide is a cytotoxic agent. The handling and preparation of Cyclophosphamide should always be in accordance with current guidelines on safe handling of cytotoxic agents. The material should not be handled by women who are pregnant or who are breast-feeding.
Adequate care and precautions should be taken in the disposal of empty vials and items (syringes, needles, etc) used in reconstitution and administration.