Cognitine Dosage/Direction for Use

Treatment should be initiated and supervised by a physician experienced in the diagnosis and treatment of Alzheimer's dementia. Therapy should only be started if a caregiver is available who will regularly monitor the intake of the medicinal product by the patient. Diagnosis should be made according to current guidelines. Memantine Hydrochloride can be taken with or without food. Adults (more than 18 years): The maximum daily dose is 20 mg daily. In order to lower the risk of side effects, this dose should be introduced gradually according to the following daily treatment plan: See Table 1.

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Elderly: On the basis of the clinical studies, the recommended dose for patients over the age of 65 years is 20 mg per day (two 10 mg tablets) as described above.
Renal impairment: In patients with mildly impaired renal function (concentration of creatine in plasma: less than 130 μmol/L), no dosage adjustment is required. In patients with severe renal impairment (creatinine clearance: 40-60 mL/min/1.73 m2), the daily dose should be 10 mg per day.