Patients w/ epilepsy. Avoid concomitant use of amantadine, ketamine, dextromethorphan, N-methyl-D-aspartate. May raise urine pH. Patients who have recent MI, under compensated cardiac insufficiency or untreated high BP. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn <18 yr.
May enhanced effects of L-dopa, dopaminergic agonists & anticholinergics. May reduce effects of barbiturate & neuroleptics. Can modify effects of antispasmodic agents, dantrolene or baclofen. Avoid concomitant use w/ NMDA-antagonists eg, amantadine, ketamine or dextromethorphan. Possible risk w/ phenytoin. Possible increased in plasma levels w/ cimetidine, ranitidine, procainamide, quinidine, quinine & nicotine. Possible of reduced serum level of hydrochlorothiazide.
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