Cladex Adverse Reactions

The most frequent adverse reactions are: Local: injection site inflammation with intravenous administration. Pain, induration, and tenderness after intramuscular injection.
Hypersensitivity: rash, pruritus, fever, eosinophilia.
Gastrointestinal: colitis, diarrhea, nausea, and vomiting.
Symptoms of pseudomembranous colitis can appear during or after antibiotic treatment. Nausea and vomiting have been reported rarely.
Less frequent adverse reactions are: Hematologic system: neutropenia, leukopenia, have been reported. Some individuals have developed positive direct Coombs' tests during treatment with cefotaxime and other cephalosporin antibiotics.
Genitourinary system: moniliasis, vaginitis.
Central nervous system: headache. Liver: transient elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum lactate dehydrogenase (LDH), and serum alkaline phosphatase levels have been reported.
Renal: as with some other cephalosporins, transient elevations of blood urea nitrogen (BUN) have been occasionally observed with cefotaxime.
Postmarketing experiences: Central nervous system: administration of high doses of beta-lactam antibiotics, including cefotaxime, particularly in patients with renal insufficiency may result in encephalopathy (e.g. impairment of consciousness, abnormal movements and convulsions). Dizziness has also been reported.
Cutaneous: as with other cephalosporins, isolated cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme have been reported. Acute generalized exanthematous pustulosis (AGEP) has also been reported.
General disorders and administration site conditions: inflammatory reactions at the injection site, including phlebitis/ thrombophlebitis.
Hematologic system: hemolytic anemia, agranulocytosis, thrombocytopenia, pancytopenia, bone marrow failure.
Hypersensitivity: anaphylaxis (e.g. angioedema, bronchospasm, malaise possibly culminating in shock), urticaria.
Kidney: interstitial nephritis, transient elevations of creatinine, acute renal failure.
Liver: hepatitis, jaundice, cholestasis, elevations of gamma-glutamyltransferase and bilirubin.