Adult & childn >12 yr 1 g every 12 hr.
Moderate-severe infections 1-2 g IV every 6-8 hr.
Severe & life-threatening infections 2 g IV every 4 hr. Max daily dose: 12 g.
Prevention of post-op infection 1 g IM or IV 30-90 min before surgery.
Cesarean surgery 1 g IV immediately after the umbilical cord is clamped & then followed by 1 g IM or IV 6-12 hr after the 1st dose.
Gonorrhea 1 g IM as a single dose.
Uncomplicated infections 2 g (1 g every 12 hr, IM or IV) or 1 g as a single dose given IM.
Moderate-severe infections 3-6 g (1-2 g every 8 hr IM or IV).
Infections requiring higher dose of antibiotic 6-8 g (2 g every 6-8 hr IV).
Life-threatening infection Up to 12 g (2 g every 4 hr IV).
Childn 100-150 mg/kg (50 mg/kg for neonates) daily in divided doses at 6-12 hr intervals.
Neonates Life-threatening conditions May be increased to 200 mg/kg (150-200 mg/kg).
Premature infant Not >50 mg/kg. If larger doses are required, use 2 g of dry powd for inj whereas for babies, premature infants & childn, use 0.5 g of prep.
Renal impairment CrCl <20 mL/min/1.73 m2 Reduce dose to ½ of the normal dose.
Patient undergoing hemodialysis 0.5-2 g daily given as a single dose & additional dose given after each dialysis period. Duration of treatment: Usually continued for at least 48-72 hr after fever has subsided or infections have been cured.
Infection due to group A β-hemolytic streptococci Continue treatment for at least 10 days.
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