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Coronary Heart Disease: In patients with coronary heart disease, simvastatin is indicated to reduce the risks of coronary death, nonfatal myocardial infarction, stroke and transient ischemic attacks (TIA).
Hyperlipidemia: Adjunct to diet to reduce elevated total-C, LDL-C, Apo B and TG and to slightly increase HDL-C in patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia or combined (mixed) hyperlipidemia when response to diet and other nonpharmacological measures are inadequate. Simvastatin therefore, lowers the LDL-C/HDL-C and the total-C/HDL-C ratios.
