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Pharmacology: Pharmacokinetics: Cefepime is given by injections as hydrochloride. It is rapidly and almost completely absorbed following intramuscular injection and mean peak plasma concentrations of about 14 and 30 micrograms/mL have been reported about 1.5 hours after doses of 500 mg and 1 gram respectively. Within 30 minutes of intravenous administration of similar doses, peak plasma concentrations of about 40 and 80 micrograms/mL are achieved. The plasma half-life of cefepime is approximately 2 hours and is prolonged in patients with renal impairment. About 20% of cefepime is bound to plasma proteins.
Cefepime is widely distributed in body tissues and fluids. High concentrations are achieved in bile. Low concentrations have been detected in breast milk.
Cefepime is eliminated principally by the kidneys and about 85% of a dose is recovered unchanged in the urine. Cefepime is substantially removed by haemodialysis.
