Cefevex Dosage/Direction for Use

Cefepime is given as hydrochloride by deep intramuscular injection, or intravenously by infusion over at least 30 minutes. Doses are expressed in terms of the equivalent amount of cefepime. 1.19 g of Cefepime hydrochloride is approximately equivalent to 1 gram of Cefepime. The usual adult dose is 1 to 2 grams daily in 2 divided doses for mild to moderate injections, increased to 4 g daily in 2 divided doses in severe infections, although up to 6 g daily in 3 divided doses has been given for febrile neutropenia. Children aged over 2 months and weighing up to 40 kg may be given 50 mg/kg twice daily; this dose may be given 3 times daily for febrile neutropenia.
Administration in Renal Impairment: Dosage of cefepime should be modified in renal impairment; after a normal initial loading dose the maintenance dosage should be adjusted according to the patient's creatinine clearance (CC) and the severity of the infection: CC 30 to 60 mL/minute: 0.5 to 2 g every 24 hours.
CC 11 to 29 mL/minute: 0.5 to 1 g every 24 hours.
CC 10 mL/minute or less: 250 to 500 mg every 24 hours.
Patients undergoing haemodialysis should be given a repeat dose (equivalent to the initial dose) after each dialysis session, while those undergoing continuous ambulatory peritoneal dialysis should receive normal recommended doses at intervals of 48 hours.