See Table 1.
Click on icon to see table/diagram/image
Dosage adjustment for patients with reduced renal function. Cefazolin may be used in patients with reduced renal function with the following dosage adjustments: Patients with creatinine clearance of 55 mL or more per minute, usual doses; creatinine clearance 35 to 54 mL/min., usual doses but at intervals of at least 8 hours; creatinine clearance 11 to 34 mL/min., ½ the usual dose every 12 hours; creatinine clearance 10 mL or less per minute, half the usual dose every 18 hours to 24 hours.
Pediatric Dosage. In children, a total daily dosage of 25 to 50 mg/kg of body weight, divided into three or four equal doses, is effective for most mild to moderately severe infections. Total daily dosage may be increased to 100 mg/kg of body weight for severe infections. Since safety for use in premature infants and in infants less than one month has not been established, the use of Cefazolin in these patients is not recommended.
In children with mild to moderate renal impairment (creatinine clearance of 70 to 40 mL/min.), 60% of the normal daily dose in equally divided dose every 12 hours should be sufficient. In patients with moderate impairment (creatinine clearance of 40 to 20 mL/min.), 25% of the normal daily dose given in equally divided doses every 12 hours should be adequate. Children with severe renal impairment (creatinine clearance of 20 to 5 mL/min.) may be given 10% of the normal daily dose every 24 hours. All dosage recommendation apply after an initial loading dose.
Direction for Reconstitution: For intramuscular injections, IV-direct (bolus) injections, or intravenous infusion, reconstitute with Sterile Water for Injection according to the following table: See table 2.
For intramuscular injections, IV-direct (bolus) injections, or intravenous infusion, reconstitute with Sterile Water for Injection according to the following table: See Table 2.
Click on icon to see table/diagram/image
Intramuscular administration: Reconstitute with 0.9% Sodium Chloride Solution or Sterile Water for Injection. Shake well until dissolved. It should be injected into a large muscle mass. Pain of injection is infrequent with Cefazolin.
Intravenous administration: Cefazolin may be administered by intravenous injection or by continuous or intermittent infusion.
Intermittent Intravenous infusion: Cefazolin can be administered along with primary intravenous fluid management program in a volume control set or in a separate, secondary bottle. Reconstituted 500 mg or 1 g of Cefazolin may be diluted in 50 to 100 mL, and 2 g in 100mL of Sterile Water for injection or one of the following intravenous solutions: 0.9% Sodium Chloride Solution, (also may be used with Sterile dextrose and 0.45% or 0.2% Sodium Chloride Solution). Lactated Ringer's Injection, 5 or 10% invert sugar in Sterile Water for Injection, Ringer's Injection.
Intravenous Injection: Dilute the reconstituted 500 mg or 1 g of Cefazolin in a minimum of 10 mL, and 2 g in a minimum of 20 mL sterile Water for Injection. Inject the solution slowly over 3 to 5 minutes. It can be administered directly into vein or through tubing.
SHAKE WELL BEFORE USING.
Sign Out
Click on icon to see table/diagram/image
Click on icon to see table/diagram/image
