Adult Mild to moderately severe infections 1.5-2 g bid or tid in equally divided doses.
Severe bacterial infection 3-4 g bid or tid in equally divided doses.
Severe, life-threatening infections (eg, endocarditis, septicemia) Up to 6 g daily.
Reduced renal function, CrCl ≥55 mL/min Usual dose,
35-54 mL/min Usual dose at least 8 hr interval,
11-34 mL/min ½ the usual dose every 12 hr,
≤10 mL/min ½ the usual dose every 18-24 hr.
Childn 12 yr (40 kg) 1.125-4.5 g daily,
7 yr (23 kg) 750 mg-3 g daily,
1 yr (10 kg) 375 mg-1.5 g daily,
4 mth (6.5 kg) 300 mg-1.2 g daily.
Severe renal impairment 10% of the normal daily dose every 24 hr.
Moderate impairment 25% of the normal daily dose in equally divided doses every 12 hr.
Mild to moderate renal impairment 60% of the normal daily dose in equally divided dose every 12 hr.
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