Various mild gastrointestinal complaints such as transient nausea and vomiting, abdominal cramps, and diarrhea have been reported during the long-term administration of oral L- or D,L-carnitine. Mild myasthenia has been described only in uremic patients receiving D,L-carnitine. Significant increases in platelet aggregation and significant hypertriglyceridemia associated with high doses of levocarnitine (3 g/day) given to hemodialysis patients have been reported.