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Pharmacology: Pharmacokinetics: Absorption: The oral mean bioavailability of Alendronic acid in women was 0.64% for doses ranging from 5 to 70 mg when administered after an overnight fast and two hours before a standardized breakfast. Bioavailability was decreased similarly to an estimated 0.46% and 0.39% when alendronate was administered one hour or half an hour before a standardized breakfast. In osteoporosis studies, alendronate was effective when administered at least 30 minutes before the first food or beverage of the day.
Distribution: Alendronic acid transiently distributes to soft tissues but is then rapidly redistributed to bone or excreted in the urine.
Biotransformation: There is no evidence that alendronate is metabolized in humans.
Elimination: Alendronic Acid, approximate 50% was excreted in the urine within 72 hours and recovered in the feces.
