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Use in Renal Failure: Amlodipine is extensively metabolized to inactive metabolites with 10% excreted unchanged in the urine. It may be used in patients at normal doses. It is not dialyzable. Half-life is prolonged in patients with impaired liver function. It should therefore be administered with caution in these patients.
Use in pregnancy & lactation: Safety for human pregnancy and lactation has not been established. Accordingly, use in pregnancy is only recommended when there is no safer alternative and when the disease itself carries greater risk for the mother and child.
