Serious allergic/hypersensitivity reactions, including life-threatening SJS, TEN & acute anaphylactic reaction/shock may occur. Pre-existing major CV diseases (eg, MI, stroke or unstable angina); previous hypersensitivity to allopurinol; patients w/ alteration of thyroid function. Treatment should not be started until an acute attack of gout has completely subsided. Discontinue use if gout flare occurs during treatment. Not recommended in patients w/ xanthine deposition (eg, malignant disease or Lesch-Nyhan syndrome); organ transplant recipient; rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Perform LFT prior to initiation of therapy & periodically thereafter. Concomitant use w/ mercaptopurine/azathioprine. May affect the ability to drive & use machine. Severe renal & hepatic impairment. Childn <18 yr.
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