Adverse effect of Losartan have been reported to be usually mild and transient, and include dizziness, headache and dose-related orthostatic hypotension. Hypotension may occur particularly in patients with volume depletion (for example those who have received high dose diuretics). Impaired renal function and, rarely rash, angioedema, and raised liver enzyme values may occur. Hyperkalemia, myalgia and arthralgia have been reported. Losartan appears less likely than ACE inhibitors to cause cough. Other adverse effects that have been reported with angiotensin II receptor antagonist include respiratory-tract disorder, back pain, gastrointestinal disturbances, fatigue and neutropenia. The most common adverse effects of Amlodipine are associated with its vasodilator action and often diminish on continued therapy. They include dizziness, flushing headache, hypotension peripheral edema, tachycardia and palpitations. Nausea and other gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain, and mental depression have also occurred. A paradoxical increase in ischaemic chest pain may occur at the start of treatment and in a few patients excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness. There have been reports of rashes (including erythema multiforme) fever, and abnormalities in liver function, including cholestasis, due to hypersensitivity reactions, Gingival hyperplasia, myalgia, tremor and impotence have been reported.
Overdose may be associated with bradycardia and hypotension.
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