Losartan: Renal artery stenosis. Hypotension in patients w/ vol depletion. Monitor serum K conc. Renal & hepatic impairment. Lactation. Amlodipine: Hypotension, poor cardiac reserve, history of heart failure. Should not be used in cardiogenic shock, MI, or in acute unstable angina; angina attack in chronic stable angina. Risk of developing heart failure in patients w/ severe aortic stenosis. Avoid abrupt w/drawal. Discontinue if ischaemic pain occurred.
Decreased conc w/ rifampicin. Decreased active metabolite conc & increased losartan conc w/ fluconazole. Increase in serum K w/ K-sparing diuretics, K supplements, or salt substitutes containing K. Reduced excretion of lithium. Further deterioration of renal function & may diminish the antihypertensive effect of losartan w/ NSAIDs including selective COX-2 inhibitors.
C09DB06 - losartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
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